Detalhe da pesquisa
1.
Phosphodiesterase in heart and vessels: from physiology to diseases.
Physiol Rev
; 104(2): 765-834, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37971403
2.
Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis.
N Engl J Med
; 386(23): 2178-2187, 2022 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35569036
3.
Uncovering the selectivity mechanism of phosphodiesterase 7A/8A inhibitors through computational studies.
Phys Chem Chem Phys
; 26(15): 11770-11781, 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38566586
4.
Discovery of novel selective phosphodiesterase1 inhibitors for the treatment of acute myelogenous leukemia.
Bioorg Chem
; 144: 107114, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38224637
5.
The epidemiology of postoperative dobutamine and phosphodiesterase inhibitors after adult elective cardiac surgery and its impact on the length of hospital stay: a post hoc analysis from the multicenter retrospective observational study.
Heart Vessels
; 39(5): 438-445, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38197915
6.
Cell dispersal by localized degradation of a chemoattractant.
Proc Natl Acad Sci U S A
; 118(6)2021 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33526658
7.
Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives.
Int J Mol Sci
; 25(2)2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279210
8.
New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling.
Molecules
; 29(3)2024 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38338326
9.
PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke.
J Neurosci
; 42(44): 8225-8236, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36163142
10.
Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment.
J Lipid Res
; 64(8): 100408, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37393952
11.
Virtual screening and in vitro experiments highlight cannabidiol as a drug-like phosphodiesterase 9 inhibitor.
Eur J Neurosci
; 57(12): 1954-1965, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36382587
12.
Cyclic Nucleotide Phosphodiesterases in Alcohol Use Disorders: Involving Gut Microbiota.
Int J Neuropsychopharmacol
; 26(1): 70-79, 2023 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36087271
13.
Characterization of 2 Novel Phosphodiesterase 2 Inhibitors Hcyb1 and PF-05180999 on Depression- and Anxiety-Like Behavior.
Int J Neuropsychopharmacol
; 26(6): 415-425, 2023 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37208298
14.
Systematic review and meta-analysis of the efficacy of olprinone and MEFV gene in treating heart failure.
Cell Mol Biol (Noisy-le-grand)
; 69(3): 82-91, 2023 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37300686
15.
Rolipram and pentoxifylline combination ameliorates the morphological abnormalities of dorsal root ganglion neurons in experimental diabetic neuropathy by reducing mitochondrial dysfunction and apoptosis.
J Biochem Mol Toxicol
; 37(11): e23459, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37431890
16.
Endothelium-Independent Vasorelaxant Effects of Sudachitin and Demethoxysudachitin, Polymethoxyflavone from the Peel of Citrus sudachi on Isolated Rat Aorta.
Biol Pharm Bull
; 46(11): 1583-1591, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37914361
17.
Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis: The ISABELA 1 and 2 Randomized Clinical Trials.
JAMA
; 329(18): 1567-1578, 2023 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37159034
18.
Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties.
Int J Mol Sci
; 24(4)2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36835244
19.
New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.
Int J Mol Sci
; 24(11)2023 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298106
20.
Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells.
Molecules
; 28(23)2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38067655